Interaction between levodopa and methyldopa.
نویسندگان
چکیده
The interaction between methyldopa and levodopa was studied in 18 patients with Parkinsonism. Together they produced a fall in blood pressure in doses which when given alone had no effect or only a slight hypotensive effect. Severe hypotension never occurred. It is reasonable to give methyldopa to hypertensive patients on levodopa but the regimen should be initiated in hospital.
منابع مشابه
Degradation of Methyldopa by Banana
Methyldopa, an antihypertensive, is a very close analogue of DOPA. Drug interaction accompanied by degradation in a banana juice mixture was reported for DOPA. However, the effect of banana on methyldopa has not been reported. Therefore, we have investigated the impact of banana juice on methyldopa. The drug and supernatant of banana pulp were mixed, and the mixture was observed for changes in ...
متن کاملRelationship between 3-O-methyldopa and the clinical effects of entacapone in advanced Parkinson's disease.
The aim of this study is to clarify the relationship between serum 3-O-methyldopa (3-OMD) and the clinical effects of entacapone. The 3-OMD and maximum serum concentration (Cmax) of levodopa were measured in 21 Parkinson's Disease patients who took 100 mg levodopa / dopa decarboxylase inhibitor. After the administration of entacapone, the 3-OMD concentration and percentage of "on" time during w...
متن کاملTime-Lag between Establishing Clinical Pharmacology Principles and Advances in Practice: The Case of Tolerance to Levodopa
Levodopa is widely used, but rarely is the topic of tolerance raised. Escalating requirement and ‘on/off’ fluctuations are often ascribed to disease progression, rather than admitted to be iatrogenic. The risk should be discussed before introduction, since ‘weaning off’ levodopa is difficult and usually unsuccessful. Dependence on the mood elevation and relief of anxiety might add to the diffic...
متن کاملTHERMODYNAMIC STUDY OF LEVODOPA DRUG ADSORPTION ON ZIGZAG BORON NITRIDE NANOTUBES BY DENSITY FUNCTIONAL THEORY (DFT) METHOD
Background & Aims: The overall goal of utilizing nanotubes in drug delivery is to treat a disease effectively with minimum side effects and control the drug release rate. With common methods of taking the medication, such as orally and intravenously, the drug is distributed throughout the body, and the whole body is affected by the drug, and adverse side effects occur. With the development of n...
متن کاملExcessive egg consumption, xanthomatosis, and hypercholesterolaemia.
methyldopa given for two to six weeks causes a rise in serum prolactin concentrations in hypertensive patients. Our studies have confirmed that patients on long-term treatment with methyldopa have raised serum prolactin concentrations. Furthermore, we have shown that even a single oral dose of methyldopa will increase serum prolactin concentrations. Basal serum prolactin levels varied considera...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- British medical journal
دوره 2 5858 شماره
صفحات -
تاریخ انتشار 1973